The healthcare industry is taking a significant leap towards new interoperability innovations with the CMS Interoperability and Patient Access final rule (CMS-9115-F). It finally addresses many of the problems associated with siloed healthcare data. This paper looks at the global interoperability problem, the CMS rule in detail, who it applies to, and the timelines. Next, we look at the implementation steps to become compliant—including data source identification, verification, and key points to consider when evaluating technologies. We then introduce WSO2 Open Healthcare and its features and highlight how it can be used to meet regulatory requirements as well as future digital transformation needs.